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The safety for the fetus of maternal use of topical corticosteroids has not been clarified, and product monographs say that they should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
In the past, there have been concerns about topical corticosteroid use and its association with orofacial clefts and restricted fetal growth due to similar effects as those caused by systemically delivered steroids, although the bioavailability of topical preparations is quite low.
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